Dr Weidong Li, Beijing Institute of Pharmacology and Toxicology, China
Dr. Weidong Li 🧑🔬 is a leading toxicology researcher at the Beijing Institute of Pharmacology and Toxicology 🇨🇳. Holding a Ph.D. in Pharmacy 🎓, he specializes in transcriptomics and investigates the molecular mechanisms of lung injury caused by toxic gases 🧪. His work applies high-throughput and single-cell RNA sequencing 🔬 to identify novel biomarkers and therapeutic targets for respiratory diseases 🌬️. Dr. Li has published in top journals including Cellular and Molecular Life Sciences 📚 and is a member of the Chinese Society of Toxicology 🧫. He is deeply committed to advancing respiratory health through cutting-edge toxicological research 🚀.
Profile :
🎓Education & Experience :
Dr. Weidong Li earned his Ph.D. in Pharmacy from the Beijing Institute of Pharmacology and Toxicology, where he specialized in transcriptomics and lung injury mechanisms 🔬. Currently serving as a Doctor at the same institute 🧑🔬, he leads pioneering research focused on toxic gas-induced pulmonary damage 🧪. Dr. Li is an expert in leveraging high-throughput and single-cell RNA sequencing technologies 🧬 to uncover molecular and cellular changes in lung tissue. He remains an active member of the Chinese Society of Toxicology 🧫, contributing to national and international advancements in the field of respiratory toxicology.
📚 Professional Development :
Dr. Li continually expands his professional competencies through active research, publication, and collaboration 📚🤝. He integrates cutting-edge bioinformatics 🧠 and transcriptomics technologies 🔍 to drive innovations in respiratory toxicology. His multidisciplinary approach merges in vivo and in vitro studies 🧫🧬, enabling discoveries of novel molecular targets and cell subtypes in lung injury. His contributions appear in respected journals such as Ecotoxicology and Environmental Safety and Journal of Translational Medicine 📝. By participating in scientific societies and submitting patents 💡📄, Dr. Li remains at the forefront of toxicological innovation and therapeutic discovery 🔬.
🔬 Research Focus :
Dr. Li’s research centers on toxicology, with a specific focus on pulmonary injury caused by toxic gas exposure 🌫️🧪. Utilizing transcriptomic techniques, including single-cell RNA sequencing 🔬, he uncovers gene expression changes and cellular dynamics in lung tissues after exposure. His integrated use of in vivo and in vitro models helps identify critical biomarkers and therapeutic targets 🎯 for respiratory disorders. This translational approach bridges basic science and clinical application 🧠💉, offering new avenues for prevention and treatment strategies in respiratory medicine 🌬️. His work significantly contributes to advancing environmental health and safety 🛡️🌱.
🏆 Awards and Honors :
Dr. Weidong Li was nominated for the prestigious Best Researcher Award in 2025 🏅, recognizing his impactful contributions to toxicological science. He is a published author 📄 in high-impact journals such as Ecotoxicology and Environmental Safety, Cellular and Molecular Life Sciences, and the Journal of Translational Medicine. His innovative research has led to the development of a patent 📊 focused on biomarkers for lung injury, which is currently published or under process. As a dedicated member of the Chinese Society of Toxicology 🎖️, Dr. Li actively contributes to the advancement of the toxicology community.
Publication Top Notes :
1. Single-cell RNA sequencing identifies cellular heterogeneity in endothelial and epithelial cells associated with nitrogen dioxide-induced acute lung injury
Journal: Ecotoxicology and Environmental Safety
Publication Date: July 2025
DOI: 10.1016/j.ecoenv.2025.118385
ISSN: 0147-6513
Authors: Weidong Li, Zhenghao Bao, Hongpeng Huang, Yingkai Ma, Yangyang Sun, Xueyang Lin, Weiqiang Sun, Shengran Wang, Ziqi Cui, Chen Yang, et al.
Summary:
This study utilized single-cell RNA sequencing to analyze lung tissue affected by nitrogen dioxide (NO₂)-induced acute lung injury (ALI). The research revealed pronounced cellular heterogeneity in endothelial and epithelial populations, highlighting specific gene expression changes that underlie tissue damage and repair. The findings contribute to understanding the pathophysiological mechanisms of NO₂-induced lung injury and may inform targeted therapeutic strategies.
2. Role of transient receptor potential ankyrin 1 in idiopathic pulmonary fibrosis: modulation of M2 macrophage polarization
Journal: Cellular and Molecular Life Sciences
Publication Date: December 2024
DOI: 10.1007/s00018-024-05219-x
ISSN: 1420-682X / 1420-9071
Authors: Yi Yang, Zhenyu Xiao, Weijie Yang, Yangyang Sun, Xin Sui, Xueyang Lin, Xinyi Yang, Zhenghao Bao, Ziqi Cui, Yingkai Ma, Weidong Li, et al.
Summary:
This article explores the involvement of TRPA1 (transient receptor potential ankyrin 1) in the progression of idiopathic pulmonary fibrosis (IPF), focusing on its role in regulating M2 macrophage polarization. The study demonstrates that TRPA1 activation contributes to fibrotic processes by enhancing M2 macrophage responses, suggesting it as a potential therapeutic target in IPF management.
3. Meldonium, as a potential neuroprotective agent, promotes neuronal survival by protecting mitochondria in cerebral ischemia–reperfusion injury
Journal: Journal of Translational Medicine
Publication Date: August 15, 2024
DOI: 10.1186/s12967-024-05222-7
ISSN: 1479-5876
Authors: Weijie Yang, Xiuxing Lei, Fengying Liu, Xin Sui, Yi Yang, Zhenyu Xiao, Ziqi Cui, Yangyang Sun, Jun Yang, Xinyi Yang, Weidong Li, et al.
Summary:
The study investigates meldonium as a neuroprotective agent in cerebral ischemia–reperfusion injury. Results show that meldonium enhances neuronal survival by preserving mitochondrial function, reducing oxidative stress, and stabilizing energy metabolism. These findings suggest that meldonium could be a promising candidate for stroke therapy.
4. Antioxidant Activity and Probiotic Proliferation and Acidifying Activity of Intracellular Polysaccharides from the Shaggy Ink Cap Medicinal Mushroom, Coprinus comatus (Agaricomycetes), under Optimal Polysaccharide Synthase Activity
Journal: International Journal of Medicinal Mushrooms
Publication Year: 2021
DOI: 10.1615/intjmedmushrooms.2021039970
ISSN: 1521-9437
Authors: Yongxia Wang, Min Sun, Weidong Li, Yongqing Zhang, Hua Zhang, Chun-Chao Han
Summary:
This paper evaluates the antioxidant and probiotic-stimulating properties of intracellular polysaccharides extracted from Coprinus comatus cultivated under optimal enzymatic conditions. Results demonstrate significant antioxidant activity and the ability to enhance probiotic proliferation and acidification, indicating potential for functional food and nutraceutical applications.
5. The Shaggy Ink Cap Medicinal Mushroom, Coprinus comatus (Agaricomycetes), Protein Attenuates Acute Alcoholic Liver Injury in Association with Changes in the Gut Microbiota of Mice
Journal: International Journal of Medicinal Mushrooms
Publication Year: 2021
DOI: 10.1615/intjmedmushrooms.2021038229
ISSN: 1521-9437
Authors: Weidong Li, Yongxia Wang, Min Sun, Yuting Liang, Xianlei Wang, Dongmei Qi, Chunchao Han
Summary:
This study demonstrates the hepatoprotective effects of protein derived from Coprinus comatus against acute alcoholic liver injury in mice. The protective effect is associated with beneficial modulation of gut microbiota, pointing toward a promising natural remedy for alcohol-induced liver damage.
Conclusion:
Dr. Weidong Li’s innovative use of modern transcriptomic technologies to explore and mitigate the health impacts of toxic gases represents a significant advancement in environmental and respiratory toxicology. His research not only enhances scientific understanding but also holds direct clinical and public health implications. Therefore, he is highly deserving of the Best Researcher Award for his pioneering work, scientific excellence, and unwavering commitment to improving respiratory health through toxicological innovation.